Research Program Overview

The faculty, Eye Clinic facilities, and Basic Science laboratories of the Department of Ophthalmology, Louisiana State University Health Shreveport, are dedicated to patient care, clinical and basic research. The research faculty of the Ophthalmology Department emphasizes the central role that evidence-based research plays in promoting knowledge-based medicine and good-medical practice. Current research efforts in the Ophthalmology sub-specialties areas are multi-focal, but all seek to understand the molecular mechanisms in ocular disease pathogenesis and the therapeutic potential and shortfalls of established and experimental treatments.

 

2005-2010 Faculty research projects include:

Steven Flynn MD, PhD

Non-Keratonizing Cervical Carcinoma in the Eye (Co-I)
Predictive Value of Board Scores in Resident Evaluation (PI)

Jesse I. Halperin

Neuro-ophthalmology guide (PI)

Marlyn P. Langford, PhD

Vaccine for Enterovirus 70 Conjunctivitis (PI)
Apoptogenicity of Muramyl Dipeptide invitro and invivo (PI)
Bacterial Peptidoglycan Induced Uveitis and Conjunctivitis (PI)
Incidence and Cause of Apoptosemia in Diabetic Children (Co-Pi/Dr. Robert McVie)
Glutamate Transporters and g-Glutamyltranspeptidase Activity in Corneal Tissue and Cells  (PI)

Chanping Liang, MD 

Posterior Segment Complications in Patients with Hepatitis C Treated with Interferon and Ribavirin (Co-I)
Nocturnal Intraocular Pressure in Patients with Sleep Apnea (PI)
Bacterial Peptidoglycan Induced UVEITIS and Conjunctivitis (Co-I)

Thomas B. Redens, MD

Bacterial Peptidoglycan Induced Uveitis and Conjunctivitis (Co-I)
g-Glutamyltranspeptidase Activity and Cataract Formation (Co-I)
Cataractogenesis: Cataract Lens Glutamate Transport (Co-I)
Glutamate Transporters and g-Glutamyltranspeptidase Activity in Corneal Tissue and Cells (Co-I)

Joel Schulman, MD

Posterior Segment Cmplications in Patients with Hepatitis C Treated with Interferon and Ribavirin (PI)

Alan Richards, MD

Treatable Gyrate Atrophy

Publications

Journal Articles

Chen, D., Duggan, C., Texada, D.E., Reden, T.B., Kooragayala, L.M. and Langford, M.P.  Immunogenicity of enterovirus 70 capsid protein VP1 and its non-overlapping N- and C-terminal fragments. Antiviral Res. 66(2-3), 111-117,2005. [PMID 15911028] 

Chen, D., Texada, D.E., Duggan, C., Liang, C., Reden, T.B., Kooragayala, L.M. and Langford, M.P.  Surface calreticulin mediates muramyl dipeptide induced apoptosis in RK13 cells. J Biol. Chem. 280(23):22425-22436, 2005. [PMID: 15817475]

Chen, D., Duggan, C., Texada, D.A., Deng, Y., Liang, C., Reden, T.B. and Langford, M.P. Induction of caspase-dependent apoptosis by enterovirus 70 in human lens epithelial SRA01/04 cells. Am J Infect Dis. 1:90-106, 2005.  ISSN 1553-6203

Langford, M.P., Chen, D., Gosslee, J.,  Misra, R.P., Redens, T.B., Texada, D.E. Intracameral toxicity of bacterial components muramyl dipeptide and staurosporine; ciliary cyst formation, epithelial cell apoptosis and necrosis.Cutaneous and Ocular Toxicol. 25(2):85-101, 2006. [PMID: 16835145]

Chen, D., Texada, D.A., Duggan, C., Deng, Y. and Langford, M.P. Caspase-3 and -7 mediate apoptosis of human Chang's conjunctival cells induced by enterovirus 70. Virology 347:307-322, 2006.  [PMID 16427675]

Zeng, G., Aldridge M.E., Tian, X., Seiler, D., Zhang, X., Jin, Y., Rao, J., Li, W., Chen, D., Langford, M.P., Duggan, C., Belldegrun, A.S. and Dubinett, S.M. Dendritic cell surface calreticulin is a receptor for NY-ESO-1: Direct interactions between tumor-associated antigen and the innate immune system.J Immunol. 15;177(6):3582-3589, 2006. [PMID 16951317]

Chen D, Langford MP, Duggan C, Madden BJ, Edwards AO. Expression of recombinant protein encoded by LOC387715 in Escherichia coli. Protein Expression and Purification 54(2):275-822007.  [PMID: 17485225]

Langford MP, Gosslee JM, Misra RP, Liang C, Redens T.B, Welbourne, TC. Apical accumulation of glutamate in GLAST-1, glutamine synthetase positive ciliary body non-pigmented epithelial cells. Clin Ophthalmol. 1:43-53, 2007.    [PMID: 19668465]

Langford MP, Redens TB, Harris NR, Jain SK, Lee S, Reddy S, McVie R. Plasma levels of cell-free apoptotic DNA ladders and gamma-glutamyltranspeptidase (GGT) in diabetic children. Exp Biol Med. 232(9):1160-1169, 2007.   [PMID: 17895524]

Gosslee JM, Misra RP, Langford MP, Vekovius B, Byrd W, Flynn SB. Orbital metastasis of keratinizing squamous cell cervical carcinoma with giant cellsA case report. Int Ophthalmol. 29(1):39-44. 2009. [PMID: 17975710]

Langford MP,  Redmond P, Chanis R, Misra RP, Redens TB. Glutamate, excitatory amino acid transporters, Xcantiporter, γ-glutamyl transpeptidase and glutamine synthetase in human corneal epithelium. Curr Eye Res2010;35:11-20. [DOI: 10.3109/02713680903461489]

 

Books

Halpern J, Flynn SB, Forman S. Neuro-ophthalmology problem solving: A user-friendly guide. San Diago, Plural Publishers, 2008.

Flynn SB. 5801 Ophthalmology questions. New York: Springer (in press, 2010).