MicroPET

Current radioisotopes used include: FDG, F-dopa, F-pencyclovir, F-gancyclovir, FMT, and F-18. Consult with the director if you are interested in using different radioisotopes.

Introduction

The MicroPET scanner is designed for positron emission tomography. This allows for study of physiologic processes in vivo. The overall process is not complicated. First, a positron-emitting isotope such as fluorine-18 is used to label a biological compound such as deoxyglucose. The positrons are positively charged electrons that are emitted from the isotope. The positron then collides with a nearby electron causing annihilation to occur. Electromagnetic energy is released form this event in the form of two 511 keV gamma rays at nearly 180° angles to one another. The 180° nature of these gamma rays enables the scanner to estimate the path at which the annihilation occurred.

Instrumentation

The Siemens CTI MicroPET R4 scanner has the highest resolution of 1.8mm and greatest absolute sensitivity of >4% due to exclusive LSO detector blocks. MicroPET® can perform whole body biodistribution imaging with an effective axial FOV of 12cm using continuous bed motion acquisition. List mode data acquisition supports static, dynamic and cardiac and/or respiratory-gated acquisition. All raw data and reconstructed data are provided to the investigator and also permanently stored to ensure that data will always be available to the investigator even after a study is completed.

Key application areas include:

  • Cardiology
  • Neurology
  • Oncology