The Office of Multicultural Affairs was established to enhance diversity within LSUHSC by assisting in the recruitment of underrepresented minorities and disadvantaged students for the Schools of Medicine, Graduate Studies, and Allied Health Professions.  The office works in collaboration with other administrative and social support services within the institution to assure successful retention of students by providing academic and career counseling and diversity training.

Since 1993 LSUHSC has taken an active role in improving the science and math background of students by soliciting federal and institutional funds to sponsor six summer enrichment programs. To demonstrate its commitment to improving quality of education for pre-college and college students grades K-16, LSUHSC has established partnerships with the Caddo and Bossier Parish School Districts, the Sci-Port: Louisiana's Science Center, and twenty - six colleges/universities in the state of Louisiana. Each partner in the pipeline provides one or more of the necessary components (students, space, structured enrichment programming, research activities, and funds) to ensure that the partnerships succeed.

The office also sponsors two student groups the Student National Medical Association (SNMA) and the Asian Pacific American Medical Student Association (APAMSA).  These students are involved in Pre-Medical Recruitment, Community Outreach, and Public Health Education.  The LSUHSC chapters implement numerous national protocols which includes the Youth Science Enrichment Program (YSEP), the Health Professional Recruitment and Exposure Program (HPREP), and the Minority Association of Pre-Health Professional Students (MAPS).  These programs are designed to encourage minority students to pursue careers in medicine and allied health professions.